Spheromers reveal robust T cell responses to the Pfizer/BioNTech vaccine and attenuated peripheral CD8+ T cell responses post SARS-CoV-2 infection
https://www.cell.com/immunity/fulltext/S1074-7613(23)00125-5?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1074761323001255%3Fshowall%3Dtrue

Highlights
•CD8+ and CD4+ T cell responses characterized using SARS-CoV-2 pMHC spheromers
•CD8+ and CD4+ T cell response kinetics are decoupled after mRNA vaccination
•Reduced peripheral CD8+ T cell responses after infection compared with mRNA vaccination
•Previous exposure limits peripheral CD8+ T cell responses after mRNA vaccination